Molecular and cellular mechanisms of pharmacoresistance in epilepsy
نویسندگان
چکیده
منابع مشابه
Molecular and cellular mechanisms of pharmacoresistance in epilepsy.
Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy, seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a substantial (approximately 30%) proportion of patients continue to have seizures despite carefully optimized drug treatment. Two concepts have been put forward to explain the development of pharmacoresistance. The tr...
متن کاملO14: Cellular and Molecular Mechanisms of Spinal Cord Trauma
لطفاً به چکیده انگلیسی مراجعه شود.
متن کامل[Island of Reil and pharmacoresistance in epilepsy].
INTRODUCTION Over the last few years surgery has been developing, with promising results, methods to treat an important number of cases of partial epilepsy that are related, to different extents, with the lobe of the insula and display pharmacoresistance. Better knowledge of the anatomofunctional particularities of this region of the cortex, new neuroimaging and neurophysiological techniques, t...
متن کاملCellular and Molecular Mechanisms Involved in Neuroinflammation after Acute Traumatic Spinal Cord Injury
Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neut...
متن کاملo14: cellular and molecular mechanisms of spinal cord trauma
the prevalence of spinal cord injury (sci) is about 2.5 million in the worldwide and more than 130,000 new injuries reported each year. regeneration in the cns versus the pns is very different from the other tissues and many factors can prevent regeneration in pns and specially cns. previous researches demonstrated that regeneration of cns can inhibit by inhibitory molecules and glial scar. the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain
سال: 2005
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awh682